Modern societies are increasingly becoming more prone to diseases related to unhealthy dietary habits. A balanced diet rich in all the essential nutrients and phytonutrients, such as carotenoids and phenolic compounds, is crucial to preserve or even improve human health and well-being. It is in this context that Healthy&ValorFOOD emerges. Healthy&ValorFOOD is divided in two research lines – ProHealthFOOD and ValorFOOD. The first, focus on health-promoting compounds, their bioavailability and biological pathway involved in some chronic disease prevention. The second research line aims at improving food properties, authenticity and safety, as well as valorizing food by-products. The whole concept of Healthy&ValorFOOD relies on the idea of promoting the health and life quality of the general population and the environment based on the improvement of the nutritional value, safety and sustainability of food. This way, Healthy&ValorFOOD will contribute to sustainable health and food systems, which is a key pillar of the European Green Deal and other societal priorities.